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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

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CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions

Kelsey Pan1, Kei Ohnuma2, Chikao Morimoto2

  • 1Internal Medicine, University of Florida, Gainesville, USA.

Cureus
|March 29, 2021
PubMed

Insights

CD26/Dipeptidyl peptidase IV (DPPIV) is a glycoprotein involved in glucose metabolism, immunity, and cancer. Understanding CD26’s roles may unlock new treatments for diabetes, autoimmune diseases, infections, and cancer.

Area of Science:

  • Biochemistry
  • Immunology
  • Oncology

Background:

  • CD26/Dipeptidyl peptidase IV (DPPIV) is a cell surface glycoprotein with diverse biological functions.
  • It plays significant roles in glucose metabolism, immune system regulation, and the development of various diseases.

Purpose of the Study:

  • To review the multifaceted roles of CD26/DPPIV in cancer, diabetes, immune-mediated disorders, and infectious diseases.
  • To highlight CD26 as a potential biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on CD26/DPPIV.
  • Analysis of CD26 expression and function in various pathological conditions.

Main Results:

  • CD26/DPPIV is implicated in type 2 diabetes, with DPPIV inhibitors (gliptins) used as oral hypoglycemic agents.
  • It plays a role in infectious diseases like COVID-19 and immune-mediated conditions such as rheumatoid arthritis and inflammatory bowel disease.
  • CD26/DPPIV expression is observed in numerous cancers, including hematologic malignancies, mesothelioma, renal cell carcinoma, and lung cancer, making it a target for anticancer therapies.

Conclusions:

  • CD26/DPPIV is a crucial molecule with implications across multiple human diseases.
  • Further research into CD26 biology may pave the way for novel therapeutic strategies.
Keywords:
cancercd26coviddiabetesdipeptidyl peptidase ivimmunologyinfectious disease

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