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High Pretreatment LDH Predicts Poor Prognosis in Hypopharyngeal Cancer
Jialing Wu1, Kaiyun You1, Changlong Chen1
1Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Frontiers in Oncology
|March 29, 2021
Summary
Elevated pretreatment lactate dehydrogenase (LDH) is a significant indicator of poor prognosis in hypopharyngeal cancer patients. This finding highlights LDH as a crucial factor for predicting patient outcomes and survival rates.
Area of Science:
- Oncology
- Cancer Research
- Biomarkers
Background:
- Lactate dehydrogenase (LDH) elevation is linked to poor prognosis in many cancers.
- The prognostic significance of pretreatment LDH in hypopharyngeal cancer is not well-established.
- This study investigates LDH as a prognostic marker in hypopharyngeal cancer.
Purpose of the Study:
- To evaluate the association between pretreatment lactate dehydrogenase (LDH) levels and clinical outcomes in hypopharyngeal cancer patients.
- To determine if LDH is an independent prognostic factor for survival in this patient cohort.
Main Methods:
- Retrospective analysis of 198 hypopharyngeal cancer patients treated surgically from 2004-2018.
- Univariate and multivariate analyses were employed to assess the prognostic role of pretreatment LDH.
- Subgroup analysis was conducted based on T stage.
Main Results:
- Patients with high pretreatment LDH levels showed significantly worse 3-year and 5-year disease-free survival (DFS) and overall survival (OS) compared to those with low LDH.
- Univariate and multivariate analyses confirmed that elevated serum LDH is an independent predictor of poor DFS and OS.
- N status and age were also significantly associated with DFS and OS.
Conclusions:
- Pretreatment elevated serum lactate dehydrogenase (LDH) is an unfavorable prognostic factor for hypopharyngeal cancer.
- LDH serves as a valuable biomarker for predicting outcomes in hypopharyngeal cancer.
- Further multicenter and prospective studies are recommended for validation.
