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Macro-TSH: A Diagnostic Challenge.

Camilla Bøgelund Larsen^1,2, Eva Rabing Brix Petersen³, Martin Overgaard^2,4

¹Department of Endocrinology, Odense University Hospital, Odense, Denmark.

European Thyroid Journal

|March 29, 2021

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This case study identifies macro-TSH, a rare condition causing falsely elevated thyroid-stimulating hormone (TSH) levels. This occurs when TSH binds to other proteins, leading to high TSH readings despite normal thyroid function.

Area of Science:

Endocrinology
Clinical Chemistry
Immunology

Background:

Analytical discrepancies between biochemical tests and clinical findings necessitate investigation.
Macro-hormones can cause artifactually elevated biochemical test results.
Thyroid-stimulating hormone (TSH) assays are susceptible to interference from macro-hormones.

Keywords:

Analytic errors Gel filtration chromatography Macro-TSH

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