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Related Concept Videos

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
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Related Experiment Video

Updated: Nov 11, 2025

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
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Thrombolysis Combined Therapy Using CuS@SiO2-PEG/uPA Nanoparticles.

Dapeng Fu1, Qingbo Fang2, Fukang Yuan3,4,5,6

  • 1Department of Vascular Surgery, The Second People's Hospital of Anhui, Province, Hefei, China.

Frontiers in Chemistry
|March 29, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces novel near-infrared light-triggered nanoparticles for controlled thrombolysis therapy. These nanoparticles safely deliver urokinase plasminogen activators (uPA) and enhance clot dissolution with laser activation, improving treatment safety and efficacy.

Keywords:
drug deliveryphotothermal therapysilica nanomaterialsthrombolysisuPA

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Thrombolysis therapy faces challenges with uncontrolled drug release, leading to hemorrhage.
  • Developing targeted drug delivery systems is crucial for improving thrombolysis safety and efficacy.

Purpose of the Study:

  • To develop a novel near-infrared (NIR) light-triggered drug delivery system for controlled release of thrombolytic drugs.
  • To investigate the potential of CuS@mSiO2-PEG (CSP) nanoparticles for targeted thrombolysis therapy.

Main Methods:

  • Synthesis of CuS@mSiO2-PEG (CSP) core-shell nanoparticles via a hydrothermal method.
  • Loading of urokinase plasminogen activators (uPA) into the mesoporous silica shell.
  • Evaluation of photothermal performance, drug loading capacity, and controlled release under NIR laser irradiation.
  • In vivo assessment of thrombolytic efficacy and thermal imaging capabilities.

Main Results:

  • CSP nanoparticles demonstrated excellent photothermal conversion efficiency (52.8%).
  • The nanoparticles exhibited high drug loading content (8.2%) and efficiency (89.6%) for uPA.
  • NIR laser irradiation effectively triggered controlled release of uPA.
  • In vivo studies showed significant thrombolytic ability and potential for infrared thermal imaging.

Conclusions:

  • The developed NIR-triggered drug delivery system (CSPA) offers a promising approach for targeted thrombolysis.
  • This system enhances therapeutic efficacy while minimizing risks associated with uncontrolled drug release.
  • The combined photothermal and drug delivery capabilities present a novel therapeutic strategy for thrombolysis.