Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.6K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.6K
Stem Cell Niche01:26

Stem Cell Niche

5.7K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.7K
Hematopoiesis01:21

Hematopoiesis

7.6K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.6K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.5K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.5K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.0K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.0K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.6K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MMP1 and PRSS23 induce PAR<sub>2</sub> biased agonism in painful oral cancers.

Communications biology·2026
Same author

IFNγ Drives Long-Term Bone Marrow Niche Dysfunction Following Doxorubicin-Based Chemotherapy.

Blood·2026
Same author

Transcription factor Etv3 controls the tolerogenic function of dendritic cells.

Science (New York, N.Y.)·2026
Same author

Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells.

Immunity·2026
Same author

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells.

Science immunology·2026
Same author

Duo-nano exosome encapsulating hydrogel boosts wound healing across xenogenic and allogenic models.

Biomaterials·2026

Related Experiment Video

Updated: Nov 11, 2025

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.1K

Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity.

Igor Dolgalev1, Anastasia N Tikhonova2

  • 1Applied Bioinformatics Laboratories, NYU School of Medicine, New York, NY, United States.

Frontiers in Cell and Developmental Biology
|March 29, 2021
PubMed
Summary

Single-cell sequencing reveals bone marrow niche complexity. This review integrates diverse studies to standardize understanding of hematopoietic stem cell niches in various conditions.

Keywords:
bone marrowcell-to cell communicationhematopoiesismicroenvironmentsingle-cell RNA-seq (scRNA-seq)single-cell ‘omicsstromal – hematopoietic cells interactions

More Related Videos

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.0K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

5.0K

Related Experiment Videos

Last Updated: Nov 11, 2025

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.1K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.0K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

5.0K

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Genomics

Background:

  • Single-cell sequencing has revolutionized stem cell research, particularly in hematopoiesis.
  • The bone marrow microenvironment is crucial for stem cell function and is increasingly studied at single-cell resolution.
  • Existing studies offer insights into niche heterogeneity under various physiological and pathological states.

Purpose of the Study:

  • To review recent single-cell sequencing studies of the bone marrow microenvironment.
  • To integrate disparate datasets for a comprehensive understanding of bone marrow niche architecture.
  • To address inconsistencies in representation and nomenclature across studies.

Main Methods:

  • Systematic literature review of single-cell sequencing studies on bone marrow niches.
  • Data integration and comparative analysis of published datasets.
  • Harmonization of nomenclature and representation standards.

Main Results:

  • Identification of key cellular components and states within the bone marrow niche.
  • Characterization of niche heterogeneity across different conditions (steady state, chemotherapy, leukemia, aging).
  • Highlighting of inconsistencies and gaps in current single-cell data.

Conclusions:

  • A unified view of bone marrow niche heterogeneity is emerging from single-cell data.
  • Standardized approaches are needed for comprehensive interpretation of bone marrow microenvironment studies.
  • This integrated overview provides a foundation for future research in hematopoietic stem cell biology.