Related Experiment Video
Updated: Nov 11, 2025
09:29
Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
Published on: August 16, 2014
12.5K
Programmable immune activating electrospun fibers for skin regeneration
Lu Chen1, Liucheng Zhang1, Hongbo Zhang2,3
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, PR China.
Bioactive Materials
|March 29, 2021
Summary
This study developed an "Inner-Outer" IL-10 electrospun fiber that controls immune responses for scarless skin regeneration. It sequentially releases IL-10 to manage inflammation and promote tissue repair.
Area of Science:
- Biomaterials Science
- Immunology
- Regenerative Medicine
Background:
- Immune cells are critical for skin healing phases.
- Sequential immune response activation is key for scarless regeneration.
Purpose of the Study:
- To construct an "Inner-Outer" IL-10-loaded electrospun fiber for controlled immune response activation.
- To achieve scarless skin regeneration by modulating inflammatory and proliferative phases.
Main Methods:
- Fabrication of an "Inner-Outer" electrospun fiber with cascade IL-10 release.
- Inhibition of excessive inflammatory cell recruitment via low-concentration IL-10 release.
- Polarization of macrophages to M2c phenotype for anti-inflammatory effects.
Main Results:
- Controlled release of IL-10 during inflammatory and proliferative phases.
- Suppression of excessive inflammation and promotion of M2c macrophage polarization.
- Inhibition of extracellular matrix overdeposition and enhanced fibroblast migration for scarless healing.
Conclusions:
- The "Inner-Outer" IL-10 electrospun fiber successfully activated sequential immune responses for scarless skin regeneration.
- This biomaterial shows potential for promoting complete tissue regeneration through immunomodulation.
