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Updated: Nov 11, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Acute Liver Failure of unclear cause? Acetaminophen-protein adducts make the diagnosis
Michael E Mullins1, Laura P James2
1Toxicology Section, Division of Emergency Medicine, Washington University School of Medicine; Saint Louis, Missouri, USA.
Abstract:
Acetaminophen poisoning remains a leading cause of acute liver failure. Some cases may be difficult to diagnose when clinical findings are equivocal, the patient's history is misleading or incomplete, or the acetaminophen concentration is low or undetectable at arrival to care. We describe a case of a medically complicated young child whose acute liver failure had two of these features. Measurement of acetaminophen-protein adducts confirmed acetaminophen as the primary cause of her liver failure.
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