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Measuring Local Anaphylaxis in Mice
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Anaphylaxis in middle-aged patients.

Wojciech Francuzik1, Magdalena Kraft1,2, Kathrin Scherer Hofmeier3

  • 1Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin.

Allergologie Select
|March 29, 2021
PubMed
Summary
This summary is machine-generated.

Middle-aged adults experiencing anaphylaxis (a severe allergic reaction) are most often triggered by insect venom. This age group also shows a higher rate of severe reactions compared to younger adults.

Keywords:
anaphylactic reactionanaphylaxisdrug allergyfood allergymiddle agesevere allergic reactionvenom allergy

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Area of Science:

  • Allergy and Immunology
  • Epidemiology
  • Gerontology

Background:

  • Anaphylaxis is a severe allergic reaction with incidence and triggers varying significantly by age.
  • Understanding age-specific patterns is crucial for effective clinical management and public health strategies.

Purpose of the Study:

  • To analyze anaphylactic episodes in adult patients, focusing on the middle-aged group (35-65 years).
  • To identify common triggers, reaction severity, and associated comorbidities in middle-aged individuals experiencing anaphylaxis.

Main Methods:

  • Retrospective analysis of 8,465 anaphylactic episodes in adult patients.
  • Stratification of patients into three age groups: <35, 35-65, and >65 years.
  • Comparison of trigger frequencies, reaction severity, and comorbidity profiles across age groups.

Main Results:

  • Insect venom (51.2%) was the leading trigger for anaphylaxis in middle-aged adults, followed by drugs (22.8%) and food (17.3%).
  • Severe reactions occurred in 40.1% of middle-aged patients, a rate higher than in those <35 years (27.6%) but lower than in those >65 years (55.6%).
  • Cardiovascular diseases and symptoms were significantly more prevalent in older age groups.

Conclusions:

  • Age is a critical factor influencing anaphylaxis triggers and severity.
  • Middle-aged adults represent a significant cohort with distinct anaphylaxis profiles, particularly concerning insect venom triggers and increased reaction severity.
  • The study highlights the importance of age-specific considerations in the diagnosis and management of anaphylaxis.