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Related Experiment Videos

Remote memory in a patient with circumscribed amnesia.

D P Salmon1, B R Lasker, N Butters

  • 1Department of Neuroscience, University of California School of Medicine, San Diego.

Brain and Cognition
|April 1, 1988
PubMed
Summary

Extensive remote memory loss can occur in patients with circumscribed amnesic syndromes, even without frontal lobe damage. This study shows retrograde amnesia is possible with isolated memory deficits.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Remote memory loss in amnesia is often attributed to frontal lobe damage affecting retrieval.
  • This study investigates if severe retrograde amnesia can exist independently of such cognitive deficits.

Observation:

  • A patient (W.H.) with a circumscribed amnesic syndrome and no apparent cortical damage was studied.
  • W.H. showed no significant cognitive deficits beyond amnesia.

Findings:

  • Impaired recall and recognition of information from the 1960s, 1970s, and 1980s.
  • Unimpaired memory for information from the 1940s and 1950s, indicating temporal gradient in retrograde amnesia.

Implications:

  • Retrograde amnesia can be a component of circumscribed amnesic syndromes.

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  • Findings challenge the notion that extensive remote memory loss solely results from frontal lobe retrieval deficits.