Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Varying patterns of association between cortical large-scale networks and subthalamic nucleus activity in Parkinson's disease.

NPJ Parkinson's disease·2026
Same author

The deep brain stimulation response network in Parkinson's disease operates in the high beta band.

Brain : a journal of neurology·2026
Same author

Effect of deep brain stimulation on dysphagia in Parkinson's disease: mechanisms, evidence, and outlook.

Frontiers in aging neuroscience·2026
Same author

Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia.

EBioMedicine·2026
Same author

Quantity and quality of care and staff knowledge regarding people with Parkinson's disease in long-term nursing care: "real-life" results from the German Care4PD study.

Frontiers in aging neuroscience·2026
Same author

Real-world multicenter assessment of sustained clinical outcomes after digital deep brain stimulation.

NPJ digital medicine·2026

Related Experiment Video

Updated: Nov 11, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.1K

Motor Evoked Potentials Improve Targeting in Deep Brain Stimulation Surgery.

Petyo Nikolov1, Verena Heil2, Christian J Hartmann1

  • 1Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Neuromodulation : Journal of the International Neuromodulation Society
|March 29, 2021
PubMed
Summary

Intraoperative motor evoked potentials (MEPs) accurately define the distance to the pyramidal tract during deep brain stimulation (DBS) surgery. This technique helps prevent postoperative capsular side effects, improving patient outcomes.

Keywords:
Capsular side effectsdeep brain stimulationmotor evoked potentials

More Related Videos

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
06:32

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

1.6K
Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.3K

Related Experiment Videos

Last Updated: Nov 11, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.1K
Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
06:32

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

1.6K
Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.3K

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Devices

Background:

  • Deep brain stimulation (DBS) surgery requires precise targeting to avoid side effects.
  • Intraoperative motor evoked potentials (MEPs) are a potential tool for identifying the pyramidal tract during surgery.

Purpose of the Study:

  • To evaluate the utility of intraoperative MEPs in defining proximity to the pyramidal tract.
  • To assess the predictive value of MEP thresholds for postoperative capsular side effects.

Main Methods:

  • MEPs were evoked during stereotactic DBS surgery using microelectrode and DBS-electrode stimulation.
  • Internal capsule proximity was correlated with MEP thresholds.
  • The predictivity of MEP thresholds for capsular side effects was calculated.

Main Results:

  • Intraoperative MEP thresholds significantly correlated with internal capsule proximity.
  • MEP thresholds demonstrated high accuracy in excluding postoperative capsular side effects.

Conclusions:

  • Intraoperative MEPs offer valuable targeting guidance in DBS surgery, particularly in asleep procedures.
  • This technique can effectively predict and prevent capsular side effects, enabling direct clinical application.