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AST/ALT Ratio and Peripheral Artery Disease in a Chinese Hypertensive Population: A Cross-Sectional Study

Hui Liu1, Xiaoyuan Zha2, Congcong Ding1

  • 1Department of Cardiovascular Medicine, 196534The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.

Angiology
|March 29, 2021
PubMed

Insights

The aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT) is linked to higher peripheral artery disease (PAD) risk in hypertensive Chinese adults. This ratio may help identify individuals at increased risk for vascular issues.

Area of Science:

  • Cardiology
  • Hepatology
  • Vascular Medicine

Background:

  • The aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT) is a known cardiovascular disease risk factor.
  • Peripheral artery disease (PAD) significantly increases the risk of cardiovascular mortality.
  • Limited research exists on the association between the AST/ALT ratio and PAD.

Purpose of the Study:

  • To investigate the correlation between the AST/ALT ratio and the risk of PAD in hypertensive patients.
  • To determine if the AST/ALT ratio can serve as a predictive marker for PAD in this population.

Main Methods:

  • Analysis of data from 10,900 hypertensive patients from the Chinese Hypertension Registry Study.
  • Statistical adjustment for potential confounding factors.
  • Assessment of PAD prevalence and its association with varying AST/ALT ratio levels (tertiles).

Main Results:

  • A prevalence of 3.2% for PAD was observed (350 patients).
  • The AST/ALT ratio was independently and positively associated with PAD risk (OR: 1.31).
  • Higher AST/ALT ratio tertiles showed a significantly increased risk of PAD, with a trend (P = .005). A ratio ≥1.65 was associated with PAD risk.

Conclusions:

  • The AST/ALT ratio is independently associated with an increased risk of PAD in Chinese adults with hypertension.
  • This ratio may serve as a practical, cost-effective tool for identifying high-risk individuals for vascular events and atherosclerosis.
  • Further research could validate the AST/ALT ratio as a screening tool for PAD.

Keywords:
ALTASTAST/ALT ratiohypertensiveperipheral artery disease

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