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Non-monotone transformation of biomarkers
Gianfranco Adimari1, Duc-Khanh To1, Monica Chiogna2
1Department of Statistical Sciences, University of Padua, Padua, Italy.
Statistical Methods in Medical Research
|March 29, 2021
Abstract:
We comment here on a recent paper in this journal, on a non-monotone transformation of biomarkers aimed at improving diagnostic accuracy. We highlight that, in a binary classification problem, the proposed transformation finds its motivation in the Neyman-Pearson lemma, so that the underlying approach is very general and it is applicable to many parametric families, other than the normal one.

