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Updated: Nov 11, 2025

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Utilizing comparative models in biomedical research.

Alexander G Little¹, Matthew E Pamenter², Divya Sitaraman³

¹Department of Biology, Queen's University, Kingston, Canada.

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology

|March 29, 2021

Summary

This summary is machine-generated.

This review introduces non-human models for biomedical physiology research. It highlights established and emerging models, emphasizing the evolving selection and validation of animal models for scientific discovery.

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Area of Science:

Comparative Biochemistry and Physiology
Biomedical Research

Background:

The use of non-human models is crucial for understanding human physiology and disease.
Model selection criteria vary across scientific disciplines, from pathology to evolutionary studies.
Established models often arise from research into unique biological processes.

Purpose of the Study:

To introduce a Special Issue on non-human models in biomedical physiology.
To discuss the dynamic nature of model selection and validation in research.
To highlight both well-known and emerging animal models for scientific inquiry.

Main Methods:

Review of current literature on animal models in physiology.
Discussion of the criteria for selecting and validating research models.
Identification of established and novel invertebrate and vertebrate models.

Main Results:

Non-human models are diverse and essential for biomedical research.
Model utility evolves with technological advancements and new discoveries.
Established models include Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, and Xenopus laevis.

Conclusions:

The selection and validation of non-human models are critical and ongoing processes.
Emerging alternative models offer new avenues for physiological research.
This review underscores the value of diverse animal models in advancing biomedical science.