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Updated: Nov 11, 2025

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation
Published on: August 8, 2016
The challenge of staying in shape: nuclear size matters
Pallavi Deolal1, Gurranna Male1, Krishnaveni Mishra2
1Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.
Abstract:
Cellular organelles have unique morphology and the organelle size to cell size ratio is regulated. Nucleus is one of the most prominent, usually round in shape, organelle of a eukaryotic cell that occupies 8-10% of cellular volume. The shape and size of nucleus is known to undergo remodeling during processes such as cell growth, division and certain stresses. Regulation of protein and lipid distribution at the nuclear envelope is crucial for preserving the nuclear morphology and size. As size and morphology are interlinked, altering one influences the other. In this perspective, we discuss the relationship between size and shape regulation of the nucleus.
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