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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

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CMR feature tracking strain patterns and their association with circulating cardiac biomarkers in patients with

Ersin Cavus1, Kai Muellerleile2, Samuel Schellert2

  • 1Clinic of Cardiology, University Heart and Vascular Center Hamburg Eppendorf, Martinistr.52, 20246, Hamburg, Germany. ersin.cavus@uke.de.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|March 29, 2021
PubMed

Insights

Cardiovascular magnetic resonance feature tracking strain (CMR-FT) detects left ventricular and left atrial dysfunction in hypertrophic cardiomyopathy (HCM) even with normal ejection fraction. Impaired strain correlates with elevated biomarkers, suggesting subclinical dysfunction in HCM.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomarkers

Background:

  • Cardiovascular magnetic resonance feature tracking strain (CMR-FT) offers prognostic insights.
  • Data on CMR-FT in hypertrophic cardiomyopathy (HCM) is limited.
  • Assessing global strain in all four cardiac chambers is crucial for understanding HCM.

Purpose of the Study:

  • To analyze global CMR-FT parameters in all four cardiac chambers in HCM patients.
  • To evaluate the association between CMR-FT parameters and NT-proBNP and cardiac troponin T (hsTnT) levels in HCM.
  • To investigate subclinical cardiac dysfunction in HCM using CMR-FT.

Main Methods:

  • Retrospective study of 144 HCM patients and 16 healthy controls using 1.5 T CMR.
  • Analysis of standard steady-state free precession cine (SSFP) CMR data with commercial software.
  • Global left ventricular (LV), right ventricular (RV), left atrial (LA), and right atrial (RA) strain assessed using feature tracking.

Main Results:

  • Impaired LV longitudinal strain (LVLAX-GLS), LV short-axis radial strain (LVSAX-GRS), and LA longitudinal strain (LALAX-GLS) were observed in HCM patients compared to controls, despite normal LVEF.
  • LV and LA strain parameters were further impaired in HCM patients with elevated NT-proBNP and/or hsTnT.
  • Moderate correlations were found between LV and LA CMR-FT parameters and NT-proBNP/hsTnT levels.

Conclusions:

  • CMR-FT effectively reveals LV and LA dysfunction in HCM, even when LVEF is preserved.
  • The correlation between impaired strain and elevated biomarkers highlights a link between subclinical functional abnormalities and HCM severity.
  • CMR-FT provides valuable insights into the functional cardiac status of HCM patients.
Abstract

Keywords:
CMR feature tracking strainCardiac biomarkerHypertrophic cardiomyopathyStrain imaging

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