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Alkaline phosphatase positive precursors of adipocytes in the human bone marrow
P Bianco1, M Costantini, L C Dearden
1Department of Human Biopathology, La Sapienza University, Rome, Italy.
British Journal of Haematology
|April 1, 1988
Abstract:
Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane-bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of 'reticular' cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.