Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.1K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancements in extracellular vesicle research.

Extracellular vesicle·2026
Same author

Beyond Pills: Integrative Approaches to Pain Relief.

Physical medicine and rehabilitation clinics of North America·2026
Same author

Breaking the Cycle: Comprehensive Strategies for Chronic Pain.

Physical medicine and rehabilitation clinics of North America·2026
Same author

Unlocking beta cell health: The clinical potential of extracellular vesicles in type 1 diabetes.

Clinical and translational medicine·2026
Same author

Cell-Based and Cell-Free Non-Invasive Prenatal Analysis of Preeclampsia: An Updated Review of Liquid Biopsy.

Biomedicines·2026
Same author

Impact of a Routine Third Trimester Ultrasound Policy on Obstetric, Neonatal and Service Delivery Outcomes in an Australian Tertiary Centre.

The Australian & New Zealand journal of obstetrics & gynaecology·2026

Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.0K

Extracellular Vesicles and Preeclampsia: Current Knowledge and Future Research Directions.

Carlos Palma1, Jessica Jellins2, Andrew Lai1

  • 1Faculty of Health Sciences, Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, Australia.

Sub-Cellular Biochemistry
|March 29, 2021
PubMed
Summary

Preeclampsia (PE) involves placental extracellular vesicles (EVs) that communicate between mother and fetus. These EVs may serve as biomarkers and therapeutic targets for managing PE complications.

Keywords:
ExosomesExtracellular vesiclesPlacentationPreeclampsiaPregnancy

More Related Videos

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

976
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

788

Related Experiment Videos

Last Updated: Nov 11, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.0K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

976
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

788

Area of Science:

  • Obstetrics and Gynecology
  • Cell Biology
  • Biochemistry

Background:

  • Preeclampsia (PE) leads to severe maternal and offspring long-term health issues.
  • Proper materno-fetal exchange relies on placental perfusion and vascular tree development.
  • Placenta-derived extracellular vesicles (EVs) are key in intercellular communication, impacting placental and endothelial cell function.

Purpose of the Study:

  • To review the role of placenta-derived EVs in preeclampsia.
  • To explore EVs as potential biomarkers and therapeutic delivery tools for PE.
  • To discuss EV biogenesis, specificity, and characterization in PE pregnancies.

Main Methods:

  • Literature review focusing on placenta-derived EVs in PE.
  • Analysis of studies on EV content and function in normal and PE pregnancies.
  • Discussion of methods for EV characterization relevant to PE.

Main Results:

  • EVs from the placenta carry bioactive molecules and specific proteins/miRNAs.
  • EV concentration and content in maternal plasma may correlate with PE severity.
  • Placenta-derived EVs can be distinguished from maternal EVs.

Conclusions:

  • Placenta-derived EVs play a significant role in PE pathophysiology.
  • EVs hold promise as diagnostic biomarkers and therapeutic agents for PE.
  • Further research into EV biogenesis and characterization is crucial for clinical application.