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Updated: Nov 11, 2025

Nanomanipulation of Single RNA Molecules by Optical Tweezers
Published on: August 20, 2014
Trans-acting regulators of ribonuclease activity
Jaejin Lee1, Minho Lee2, Kangseok Lee3
1Department of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea.
Abstract:
RNA metabolism needs to be tightly regulated in response to changes in cellular physiology. Ribonucleases (RNases) play an essential role in almost all aspects of RNA metabolism, including processing, degradation, and recycling of RNA molecules. Thus, living systems have evolved to regulate RNase activity at multiple levels, including transcription, post-transcription, post-translation, and cellular localization. In addition, various trans-acting regulators of RNase activity have been discovered in recent years. This review focuses on the physiological roles and underlying mechanisms of trans-acting regulators of RNase activity.
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