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The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis

Chia Siang Kow1, Hamid A Merchant2, Zia Ul Mustafa3

  • 1School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia. chiasiang_93@hotmail.com.

Pharmacological Reports : PR
|March 29, 2021
PubMed
Abstract

Insights

This meta-analysis suggests ivermectin may reduce mortality in COVID-19 patients. Further large-scale trials are needed to confirm these preliminary findings on ivermectin for coronavirus disease 2019.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Clinical Trials

Background:

  • Numerous studies have explored ivermectin's impact on COVID-19 mortality.
  • A comprehensive meta-analysis is required to synthesize existing randomized controlled trial (RCT) data.

Purpose of the Study:

  • To conduct a meta-analysis of RCTs evaluating ivermectin's effect on mortality in COVID-19 patients.
  • To determine the overall risk of mortality associated with ivermectin use in this population.

Main Methods:

  • Systematic literature search across major databases (PubMed, Cochrane, Google Scholar) and preprint repositories.
  • Meta-analysis using random-effects and inverse variance heterogeneity models.
  • Risk of bias assessment using the Cochrane risk-of-bias tool (Version 2).

Main Results:

  • Six RCTs with 1255 patients (658 ivermectin, 597 control) were included.
  • Four of the six trials exhibited a high risk of bias.
  • A preliminary pooled odds ratio of 0.21 (95% CI: 0.11-0.42) suggested a mortality benefit for ivermectin.

Conclusions:

  • A preliminary beneficial effect of ivermectin on COVID-19 mortality was observed.
  • Further high-quality, large-scale RCTs are necessary to validate these findings.
  • The current evidence warrants continued investigation into ivermectin's role in managing COVID-19.
Keywords:
BiasCOVID-19Clinical trialIvermectinMortality

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