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Related Experiment Video

Updated: Nov 11, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Scaling Up DNA Origami Lattice Assembly.

Yang Xin¹, Boxuan Shen², Mauri A Kostiainen²

¹Technical and Macromolecular Chemistry, Paderborn University, Warburger Str. 100, 33098, Paderborn, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|March 29, 2021

Summary

This study demonstrates scalable, homogeneous fabrication of DNA origami lattices over large areas. The cost-effective nanopatterning technique shows great promise for creating functional nanoscale surfaces.

Keywords:

DNA origami lattice formation molecular lithography self-assembly topological analysis

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Last Updated: Nov 11, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Published on: May 8, 2015

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

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Published on: April 12, 2019

Design and Synthesis of a Reconfigurable DNA Accordion Rack

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Published on: August 15, 2018

Area of Science:

Nanotechnology
Materials Science
Biophysics

Background:

DNA origami enables precise nanoscale lattice fabrication.
Scalability has been a key challenge for practical applications.

Purpose of the Study:

To explore the scalability of surface-assisted DNA origami assembly.
To demonstrate large-area, homogeneous fabrication of DNA origami lattices.

Main Methods:

Surface-assisted hierarchical assembly on mica-electrolyte interfaces.
Atomic Force Microscopy (AFM) for topological analysis.
Fluorescence microscopy for surface coverage assessment.

Main Results:

Homogeneous polycrystalline DNA origami lattice formed over 18.75 cm².
Minimal variations in lattice quality and order observed across the surface.
Highly uniform surface coverage demonstrated with minor edge effects.

Conclusions:

Surface-assisted assembly is a scalable method for DNA origami lattices.
This technique offers a cost-effective route for large-area nanopatterning.
Potential for fabricating advanced functional surfaces is significant.