Cyrene™ as a Neoteric Bio-Based Solvent for Catalyst-Free Microwave-Assisted Construction of Diverse Bipyridine...

An environment-friendly synthetic protocol was developed to access polyfunctionalized bipyridines from readily available amines, chromone-3-carboxaldehydes, and pyridinylacetonitriles under catalyst- and additive-free conditions using the bio-renewable neoteric solvent dihydrolevoglucosenone (Cyrene™). In this strategy, amines served as both a mild-base promoter and a substrate. In addition, water was the only by-product of this reaction. This multi-component protocol provided highly diverse 2,3-, 3,3-, and 3,4-bipyridines in good-to-excellent yields. Operational simplicity, short reaction time, excellent atom economy, and easily obtainable substrates are among the features of this microwave-assisted synthesis. Additionally, the compounds synthesized via this method have demonstrated the ability to detect heavy metals, specifically mercury(II), copper(II), and iron (III) ions.