Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.8K
Bone Remodeling01:40

Bone Remodeling

39.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.5K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.5K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.3K
What is the Skeletal System?01:02

What is the Skeletal System?

55.2K
Overview
55.2K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

4.4K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise for fracture prevention - evidence and consensus-based practice guideline of the osteology umbrella association (DVO).

BMC endocrine disorders·2026
Same author

[Physical training for fracture prevention : Evidence- and consensus-based practice recommendations of the updated DVO guideline].

Orthopadie (Heidelberg, Germany)·2025
Same author

Establishment of human periodontal ligament cell lines with <i>ALPL</i> mutations to mimic dental aspects of hypophosphatasia.

Frontiers in cell and developmental biology·2025
Same author

A perspective on muscle phenotyping in musculoskeletal research.

Trends in endocrinology and metabolism: TEM·2024
Same author

Effects of high-intensity training on fatty infiltration in paraspinal muscles in elderly males with osteosarcopenia - the randomized controlled FrOST study.

BMC geriatrics·2024
Same author

Identification of NOTCH-driven matrisome-associated genes as prognostic indicators of multiple myeloma patient survival.

Blood cancer journal·2023

Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

791

[Osteoporosis-Update 2021].

Franz Jakob1,2

  • 1Bernhard-Heine-Centrum für Bewegungsforschung Würzburg.

Deutsche Medizinische Wochenschrift (1946)
|March 29, 2021
PubMed
Summary
This summary is machine-generated.

New anabolic osteoporosis drugs like romosozumab offer rapid bone formation and significant fracture risk reduction. Personalized treatment strategies are crucial for long-term osteoporosis management.

More Related Videos

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.1K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.9K

Related Experiment Videos

Last Updated: Nov 11, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

791
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.1K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.9K

Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Osteoporosis management is evolving with new data and drug development.
  • Sclerostin-antibody romosozumab is a novel anabolic drug for osteoporosis.
  • Current therapeutic strategies are being refined by health authorities.

Purpose of the Study:

  • To review the advancements in osteoporosis management, focusing on novel anabolic agents.
  • To discuss the mechanism of action and clinical implications of romosozumab.
  • To highlight the importance of individualized, long-term treatment strategies for osteoporosis.

Main Methods:

  • Review of recent clinical trial data and health authority guidelines.
  • Analysis of the pharmacological action of romosozumab and teriparatide.
  • Discussion of differential therapeutic strategies based on drug mechanisms and patient profiles.

Main Results:

  • Romosozumab rapidly stimulates bone formation and increases bone mineral density, reducing fracture risk by over 70% at the lumbar spine.
  • Romosozumab and teriparatide represent distinct anabolic strategies, differing in bone remodeling versus modeling.
  • Health authorities now permit anabolic agents as first-line treatment for severe osteoporosis, easing prior restrictions.

Conclusions:

  • Romosozumab offers a significant advancement in osteoporosis treatment, particularly for severe cases.
  • Individualized treatment plans, considering drug mechanisms and patient factors, are key for long-term osteoporosis management.
  • Maintaining therapeutic success requires stabilization with long-acting bisphosphonates if biological treatments are discontinued.