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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
[Invasive fungal infections in ICU patients - What's New?]
Matthias Kochanek1,2,3, Philipp Köhler1,2,4
1Klinik I für Innere Medizin, Uniklinik Köln.
Abstract:
Invasive fungal infections are gaining increasing importance in intensive care medicine. The aim of this article is to present an update on recent developments in the field of invasive fungal infection in critically ill patients. Particular emphasis is placed on the recently described invasive mold infections in patients with acute respiratory distress syndrome due to influenza or COVID-19. Detecting high-risk patients and the optimal diagnostic and therapeutic strategies play a decisive role to improve outcome.
Insights
Invasive fungal infections are a growing concern in intensive care, especially in critically ill patients with acute respiratory distress syndrome (ARDS) from influenza or COVID-19. Early detection and tailored treatment are crucial for improving patient outcomes.
Area of Science:
- Critical care medicine
- Infectious diseases
- Mycology
Background:
- Invasive fungal infections (IFIs) pose a significant and increasing threat in intensive care units (ICUs).
- Recent outbreaks highlight the association between IFIs and severe respiratory illnesses like influenza and COVID-19.
Purpose of the Study:
- To provide an updated overview of recent advancements in managing IFIs in critically ill patients.
- To focus on emerging invasive mold infections in patients with acute respiratory distress syndrome (ARDS).
Main Methods:
- Review of current literature and clinical guidelines.
- Analysis of recent case reports and epidemiological data related to IFIs in ARDS patients.
Main Results:
- Invasive mold infections are increasingly recognized in patients with influenza- and COVID-19-associated ARDS.
- Identification of specific patient populations at higher risk for IFIs is essential.
Conclusions:
- Optimal diagnostic and therapeutic strategies are critical for improving the prognosis of IFIs in the ICU.
- Prompt recognition and management of high-risk patients can significantly impact outcomes.
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