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LncRNA AC105942.1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation

Ru-Yi Zhang1, Chang-Meng Wu1, Xiu-Mei Hu1

  • 1Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

DNA and Cell Biology
|March 30, 2021
PubMed

Insights

Long noncoding RNA AC105942.1 inhibits vascular smooth muscle cell proliferation, a key factor in atherosclerosis. This study reveals AC105942.1

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • RNA Biology

Background:

  • Vascular smooth muscle cell (VSMC) proliferation is central to atherosclerosis.
  • The role of long noncoding RNAs (lncRNAs) in VSMC activation and vascular diseases remains unclear.
  • Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is involved in lncRNA functions.

Purpose of the Study:

  • To investigate the roles of lncRNA AC105942.1 and hnRNPA2/B1 in pathological VSMC proliferation.
  • To elucidate the underlying molecular mechanisms in vitro.
  • To explore their potential as therapeutic targets for atherosclerosis.

Main Methods:

  • Comparative analysis of lncRNA AC105942.1 and hnRNPA2/B1 expression in atherosclerotic plaques versus normal artery tissues.
  • In vitro experiments assessing the effect of enhanced lncRNA AC105942.1 on Ang II-induced VSMC proliferation.
  • Investigation of the regulatory pathways involving hnRNPA2/B1, CDK4, and p27.

Main Results:

  • lncRNA AC105942.1 was downregulated, while hnRNPA2/B1 was upregulated in atherosclerotic plaques.
  • Increased lncRNA AC105942.1 expression significantly inhibited Ang II-induced VSMC proliferation.
  • lncRNA AC105942.1 was found to downregulate hnRNPA2/B1, subsequently affecting CDK4 and p27 levels.

Conclusions:

  • lncRNA AC105942.1 protects against atherosclerosis by suppressing VSMC proliferation via downregulation of hnRNPA2/B1.
  • lncRNA AC105942.1 and hnRNPA2/B1 present potential diagnostic and therapeutic targets for atherosclerosis-related diseases.
Keywords:
cell proliferationhnRNPA2/B1lncRNA AC105942.1long noncoding RNAvascular smooth muscle cell

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