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Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
Published on: January 12, 2018
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The associations between red cell distribution width and plasma proteins in a general population
Jingxue Pan1, Yan Borné2, Marju Orho-Melander2
1Department of Clinical Sciences, Lund University, CRC Hus 60 plan 13, Jan Waldenströms gata 35, 20502, Malmö, Sweden. jingxue.pan@med.lu.se.
Clinical Proteomics
|March 30, 2021
Summary
High red cell distribution width (RDW) is linked to cardiovascular disease (CVD) risk. This study identified 11 plasma proteins associated with RDW, potentially explaining CVD risk mechanisms.
Area of Science:
- Cardiovascular Disease Research
- Proteomics
- Hematology
Background:
- High red cell distribution width (RDW) is an emerging risk factor for cardiovascular diseases (CVDs).
- The underlying mechanisms connecting elevated RDW to CVD pathogenesis are not fully understood.
- Targeted proteomics offers a potential avenue to explore these associations.
Purpose of the Study:
- To investigate the relationship between RDW and plasma proteins involved in CVD.
- To identify specific proteins that may mediate the association between high RDW and cardiovascular risk.
Main Methods:
- A population-based cohort study (Malmö Diet and Cancer-Cardiovascular Cohort, n=4726) was utilized.
- RDW and 88 plasma proteins were measured, with a discovery (2/3) and replication (1/3) sample design.
- Multiple linear regression with confounder adjustments was employed, followed by Bonferroni correction for significance.
Main Results:
- Thirteen plasma proteins showed significant associations with RDW in the discovery cohort.
- Eleven of these proteins, including SIRT2, GDF-15, MMP-7, HGF, CHI3L1, IL-8, CD40-L, U-PAR, and MMP-3, were validated in the replication cohort.
- Stem cell factor (SCF) was inversely associated with RDW.
Conclusions:
- This study identified several plasma proteins associated with RDW in a large cohort.
- These proteins may represent key mediators linking high RDW to increased cardiovascular risk.
- Further research into these protein-RDW associations could elucidate CVD pathogenesis.
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