Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality?

Area of Science:

• Immunology
• Infectious Diseases
• Physiology

Background:

• COVID-19 pandemic has seen rising mortality.
• Fever is a common symptom, but its beneficial role in recovery is under-investigated.
• Current patient care may overlook the therapeutic potential of fever.

Purpose of the Study:

• To explore the role of fever in the immunological response to COVID-19.
• To highlight the importance of harmonizing fever, fluid, and food management in patient care.
• To advocate for further research into fever as a natural defense mechanism against viral infections.

Main Methods:

• Review of existing animal and human studies on fever suppression during viral infections.
• Analysis of physiological responses to fever, including hormonal and fluid balance.
• Examination of the impact of fever on gastrointestinal function and energy reallocation.

Main Results:

• Fever suppression may increase morbidity and prolong viral illnesses.
• Elevated fever increases antidiuretic hormone, necessitating conservative fluid management.
• Fever redirects energy to the immune response, impacting gastrointestinal function.

Conclusions:

• Fever is a critical, yet often overlooked, component of the immune response to COVID-19.
• Integrating fever management with appropriate fluid and nutritional support can aid recovery.
• Further investigation into harnessing fever's natural protective mechanisms is warranted.