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Updated: Nov 11, 2025

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat
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Degenerative cervical myelopathy.

L Marie-Hardy1, H Pascal-Moussellard1

  • 1Orthopaedic surgery department, Pitié-Salpétrière hospital, 47, boulevard de l'Hôpital, 75013 Paris, France.

Revue Neurologique
|March 30, 2021
PubMed
Summary
This summary is machine-generated.

Degenerative cervical myelopathy (DCM) is often underdiagnosed due to varied symptoms. Early diagnosis and management are crucial to prevent severe neurologic disability and acute decompensation.

Keywords:
Cervical fusionCervical spineDegenerativeDisabilityMRI

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Area of Science:

  • Neurology
  • Genetics

Background:

  • Degenerative cervical myelopathy (DCM) is a common cause of spinal cord dysfunction.
  • It often presents with diverse symptoms, leading to underdiagnosis.
  • The condition can result in significant neurologic disability.

Purpose of the Study:

  • To review key aspects of degenerative cervical myelopathy.
  • To discuss diagnostic challenges, including clinical and radiological findings.
  • To explore recent discoveries in DCM pathophysiology and management.

Main Methods:

  • Literature review of clinical and genetic studies on DCM.
  • Analysis of diagnostic criteria and management strategies.
  • Examination of pathophysiological mechanisms and genetic links.

Main Results:

  • DCM diagnosis is challenging due to symptom variability.
  • Genetic mutations are increasingly identified, contributing to understanding pathophysiology.
  • Acute decompensation is a significant risk.

Conclusions:

  • Improved diagnostic approaches are needed for DCM.
  • Understanding genetic factors can inform targeted therapies.
  • Consensus on management strategies is essential to mitigate risks.