Related Experiment Videos
Diffusion and uptake of dopamine in rat caudate and nucleus accumbens compared using fast cyclic voltammetry
J A Stamford1, Z L Kruk, P Palij
1Department of Pharmacology, London Hospital Medical College, U.K.
Brain Research
|May 17, 1988
Abstract:
Fast cyclic voltammetry was used in the caudate and nucleus accumbens of anaesthetised rats to study the release and reuptake of dopamine following stimulation of the median forebrain bundle. Dopamine uptake was significantly slower in accumbens than caudate, indicating a lower number of functional uptake sites. This implies that dopamine may be able to diffuse further from its sites of release in nucleus accumbens than in caudate and thus may have a neuromodulator role in this region.