Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coagulation01:06

Coagulation

588
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
588
Coagulation01:09

Coagulation

8.7K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
8.7K
Introduction to Hemostasis01:05

Introduction to Hemostasis

11.5K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
11.5K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

10.6K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
10.6K
Disorders of Hemostasis01:24

Disorders of Hemostasis

1.5K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.5K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

7.7K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Prediction to Action: Why Bleeding Risk in Cardiac Surgery Still Eludes Us in the Era of Artificial Intelligence.

Anesthesiology·2026
Same author

The Missing Beat of the New Kids on the Block:Type O Whole Blood and Cryopreserved Platelet Concentrates in High-Risk Bleeding Settings.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Incidence and Characteristics of Residual Heparin Effect in Cardiothoracic Surgical Patients using Sonorheometry Clot Time Ratio.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Use of Argatroban as a Heparin Alternative in Cardiac Surgery - A Rapid Review of Case Reports and Series.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Elective Coronary Artery Bypass Graft Complicated by Severe and Persistent Postoperative Bleeding and Newly Diagnosed Factor XIII Deficiency.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Perioperative discontinuation of SGLT2-inhibitors and cardiac complications after noncardiac surgery: secondary analysis of two prospective observational cohort studies.

British journal of anaesthesia·2026

Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

971

The Year in Coagulation: Selected Highlights from 2020.

Prakash A Patel1, Reney A Henderson2, Daniel Bolliger3

  • 1Department of Anesthesiology, Cardiothoracic Division, Yale University School of Medicine, New Haven, CT.

Journal of Cardiothoracic and Vascular Anesthesia
|March 30, 2021
PubMed
Summary

This review summarizes key 2020 advancements in coagulation for cardiac surgery, including transfusion, antiplatelet/anticoagulant therapies, and COVID-19 effects.

Keywords:
COVID-19ECMOanticoagulantsantiplateletcoagulationcoronavirus disease 2019extracorporeal membrane oxygenationfactor concentratestransfusionviscoelastic testing

More Related Videos

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

9.0K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.1K

Related Experiment Videos

Last Updated: Nov 11, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

971
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

9.0K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.1K

Area of Science:

  • Anesthesiology
  • Cardiovascular Surgery
  • Hematology

Background:

  • The Journal of Cardiothoracic and Vascular Anesthesia publishes annual reviews on critical topics.
  • Coagulation management is vital in cardiac surgery.
  • The 2020 literature presented significant developments in this field.

Purpose of the Study:

  • To provide a focused summary of the most important coagulation topics from the prior year's literature.
  • To highlight advancements relevant to cardiac surgery patients.

Main Methods:

  • A comprehensive literature review of coagulation topics from 2020.
  • Focused summary of key research and clinical findings.

Main Results:

  • Key areas reviewed include allogeneic transfusion practices.
  • Advances in antiplatelet and anticoagulant therapy were discussed.
  • The role of factor concentrates and coagulation testing was examined.
  • Impact of mechanical circulatory support and COVID-19 on coagulation was analyzed.

Conclusions:

  • Staying abreast of coagulation literature is crucial for optimal cardiac surgery outcomes.
  • The 2020 findings offer valuable insights for clinical practice.
  • Continued research in coagulation is essential for patient care.