Ultrasound-based screening and characterization of an atypical clear-cell sarcoma of the hand: A case report

Clear cell soft-tissue sarcoma is a rare tumor typically presenting in the lower extremities.

We present a middle-aged woman with a 2-month history of a growing mass in the right hand dorsum. Initial biopsy reported findings consistent with benign fibroma, however, high-resolution ultrasound screening revealed a multilobulated, heterogeneous, and hypervascular mass highly suspicious for malignancy. Excisional biopsy, histology, and immunohistochemistry confirmed the diagnosis of clear-cell soft tissue sarcoma. The patient presented no evidence of recurrence at 6-month follow-up.

Ultrasound is an accessible and cost-effective modality for screening and management guidance for soft-tissue sarcomas.