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Atypical Unilateral Lower-Limb Relapse of Breast Cancer
Noeuveglise Alexandra1, Becker Stephanie2, Vera Pierre2
1From the Departments of Radiotherapy.
Clinical Nuclear Medicine
|March 30, 2021
Summary
A breast cancer relapse was detected three years after initial treatment. Elevated tumor markers and bone scintigraphy confirmed metastatic osteolytic lesions, indicating recurrence.
Area of Science:
- Oncology
- Medical Imaging
- Pathology
Background:
- A case of a rare late-stage breast cancer recurrence is presented.
- The patient, an 84-year-old woman, underwent treatment for Grade III, RH+, HER2- infiltrative ductal carcinoma in 2017.
Observation:
- Elevated CA-15.3 tumor marker levels were noted in April 2020, with no initial clinical signs of relapse.
- Subsequent development of left foot pain led to bone scintigraphy, revealing osteolytic lesions in the lower limb.
Findings:
- 99mTc-DPD bone scintigraphy identified multiple osteolytic lesions, indicative of metastatic disease.
- Echo-guided tibial biopsies confirmed the metastatic lesions originated from the primary breast adenocarcinoma, confirming relapse.
Implications:
- This case highlights the importance of vigilant monitoring for late recurrences in breast cancer patients.
- Advanced imaging and biopsy are crucial for diagnosing distant metastases even with initially negative clinical evaluations.
- Understanding recurrence patterns aids in refining long-term surveillance strategies for breast cancer survivors.
