Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

106
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
106
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

146
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
146
Development of the Heart01:27

Development of the Heart

1.6K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
1.6K
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

110
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
110
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

197
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
197
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

141
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
141

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19.

Critical care explorations·2026
Same author

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell renewal in idiopathic pulmonary fibrosis.

The Journal of clinical investigation·2026
Same author

Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

Respiratory viral infections prime accelerated lung cancer growth.

Cell·2026
Same author

Cellular heterogeneity of HTII-280-labeled epithelial cells in healthy and fibrotic human lungs.

American journal of respiratory and critical care medicine·2026
Same author

Dipeptidyl peptidase-3 to predict respiratory outcomes in patients hospitalized with COVID-19: A secondary analysis of a multicenter randomized trial.

Journal of critical care·2026
Same journal

Erratum.

Journal of cardiac surgery·2023
Same journal

Validity of direct bilateral axillary arterial cannulation in emergency surgery for acute type A aortic dissection.

Journal of cardiac surgery·2023
Same journal

Evaluation of midterm outcomes after Shone's complex surgery: Analysis of reoperation and mortality risk factors.

Journal of cardiac surgery·2023
Same journal

Subannular procedures on papillary muscles for secondary mitral valve regurgitation repair.

Journal of cardiac surgery·2022
Same journal

Safety of apixaban and rivaroxaban compared to warfarin after cardiac surgery.

Journal of cardiac surgery·2022
Same journal

Impact of rapid rehabilitation surgery on perioperative nursing in patients undergoing cardiac surgery: A meta-analysis.

Journal of cardiac surgery·2022
See all related articles

Related Experiment Video

Updated: Nov 11, 2025

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.7K

Development of a biventricular conversion program: A new paradigm.

Christopher Greenleaf1, Raina Sinha2, Zachary Cerra1

  • 1Children's Heart Institute, Memorial Hermann Hospital, University of Texas Health McGovern Medical School, Houston, Texas, USA.

Journal of Cardiac Surgery
|March 30, 2021
PubMed
Summary
This summary is machine-generated.

Biventricular (BiV) conversion offers a feasible alternative for single ventricle palliation, demonstrating low mortality and improved ventricular function. However, the risk of reintervention remains significant.

Keywords:
cardiovascular researchcongenital heart disease

More Related Videos

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.9K
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.7K

Related Experiment Videos

Last Updated: Nov 11, 2025

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.7K
Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.9K
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.7K

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Surgery
  • Cardiac Physiology

Background:

  • Single ventricle palliation is employed when both ventricles cannot be utilized, often due to small size or technical challenges.
  • Complications associated with the Fontan procedure have prompted exploration of alternative surgical pathways.
  • A novel biventricular (BiV) conversion program was established to address these limitations.

Purpose of the Study:

  • To evaluate the fundamental principles and clinical outcomes of a new biventricular (BiV) conversion program.
  • To assess the feasibility and effectiveness of converting single ventricle physiology to biventricular physiology.
  • To analyze patient selection criteria and the impact of BiV conversion on cardiac function.

Main Methods:

  • Retrospective review of a prospectively collected database (Children's Memorial Hermann Heart Institute Society of Thoracic Surgeon's Database) from July 2017 to July 2020.
  • Inclusion criteria focused on patients undergoing BiV conversion.
  • Analysis of pre- and post-operative cardiac pressures and patient survival.

Main Results:

  • Thirteen patients underwent BiV conversion, with malposed great arteries and VSD being the most common diagnosis (31%).
  • A significant increase in left ventricular end-diastolic pressure was observed postoperatively (p < .05).
  • At a median follow-up of 22.6 months, 92% of patients were alive, indicating favorable short-term survival.

Conclusions:

  • Biventricular (BiV) conversion is a viable strategy with acceptable short-term clinical results.
  • While mortality risk is low, the need for reintervention remains a significant consideration, consistent with other studies.
  • Further research is warranted to optimize patient selection and long-term outcomes for BiV conversion.