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Updated: Nov 11, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Biotransformation of sesquiterpenoids: a recent insight
Nurul Iman Aminudin1, Munirah Ridzuan1, Deny Susanti1
1Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia (IIUM), Kuantan, Pahang 25200, Malaysia.
Abstract:
Sesquiterpenoids have been identified as natural compounds showing remarkable biological activities found in medicinal plants. There is great interest in developing methods to obtain sesquiterpenoids derivatives and biotransformation is one of the alternative methods for structural modification of complex sesquiterpenes structures. Biotransformation is a great drug design tool offering high selectivity and green method. The present review describes a comprehensive summary of biotransformation products of sesquiterpenoids and its structural modification utilizing a variety of biocatalysts including microorganisms, plant tissue culture and enzymes. This review covers recent literatures from 2007 until 2020 and highlights the experimental conditions for each biotransformation process.
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