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A review targeting the infection by CHIKV using computational and experimental approaches
Durgesh Kumar1,2, Kamlesh Kumari3, Ramesh Chandra2
1Department of Chemistry, Atma Ram Sanatan Dharma College, University of Delhi, New Delhi, India.
Journal of Biomolecular Structure & Dynamics
|March 30, 2021
Summary
Chikungunya virus (CHIKV) causes fever and is spread by mosquitoes. Researchers are exploring theoretical and experimental methods to inhibit CHIKV, focusing on the nsP3 protein, as no vaccine currently exists.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Fever, a body temperature rise above 100.4°F, often indicates illness or infection.
- Chikungunya virus (CHIKV) transmitted by mosquitoes causes Chikungunya fever (CHIKF).
- Current medical options lack effective vaccines or treatments for early CHIKV detection and management.
Purpose of the Study:
- To review current literature on Chikungunya virus (CHIKV).
- To explore the pathogenesis of CHIKV infections.
- To summarize theoretical and experimental approaches for CHIKV inhibition.
Main Methods:
- Literature review of CHIKV research.
- Analysis of CHIKV genomic structure and protein functions.
- Examination of theoretical and experimental CHIKV inhibition strategies.
Main Results:
- CHIKV has a genomic structure with two open reading frames (ORFs) encoding nonstructural and structural proteins.
- The nonstructural protein nsP3 is identified as a key target due to its catalytic activity.
- Various theoretical and experimental approaches are being investigated for CHIKV inhibition.
Conclusions:
- There is an urgent need for effective vaccines and treatments for CHIKV infection.
- Targeting viral proteins like nsP3 offers potential therapeutic strategies.
- Continued research into CHIKV pathogenesis and inhibition is crucial for disease control.
