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Effect of a dedicated mitral heart team compared to a general heart team on survival: a retrospective, comparative,
Peyman Sardari Nia1,2, Jules R Olsthoorn1, Samuel Heuts1
1Department of Cardiothoracic Surgery, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands.
Insights
A dedicated heart team approach for mitral valve disease significantly improves patient survival compared to a general heart team. Following heart team recommendations, whether general or dedicated, also reduces mortality risk.
Area of Science:
- Cardiology
- Cardiac Surgery
- Clinical Outcomes
Background:
- The heart team approach is a Class I recommendation in US and European guidelines for mitral valve disease.
- However, supporting evidence for its comparative effectiveness is limited.
- This study aimed to compare survival data between general and dedicated heart teams for mitral valve disease.
Purpose of the Study:
- To compare the survival rates of patients with mitral valve disease managed by a general heart team versus a dedicated mitral valve heart team.
- To evaluate the impact of adhering to heart team recommendations on patient mortality.
Main Methods:
- Retrospective cohort study including 1145 patients evaluated for mitral valve disease.
- Patients were divided into two groups: general heart team (2009-2014) and dedicated mitral valve heart team (2014-2018).
- Decision-making was prospectively recorded, and overall survival was the primary endpoint.
Main Results:
- The dedicated heart team group (n=641) showed a 5-year survival probability of 0.74, compared to 0.70 for the general heart team group (n=504) (P=0.040).
- Patients managed by the dedicated heart team had a 29% lower adjusted risk of mortality (HR 0.71, P=0.019).
- Adherence to dedicated heart team advice reduced mortality by 61%, while adherence to general heart team advice reduced it by 43%.
Conclusions:
- Management of mitral valve disease by a dedicated heart team is associated with significantly higher survival rates.
- These survival benefits are independent of treatment allocation, mitral valve pathology, and patient baseline characteristics.
- Following heart team recommendations is crucial for improving survival in mitral valve disease patients.
Objectives:
Although in both the US and European guidelines the 'heart team approach' is a class I recommendation, supporting evidence is still lacking. Therefore, we sought to provide comparative survival data of patients with mitral valve disease referred to the general and the dedicated heart team.
Methods:
In this retrospective cohort, patients evaluated for mitral valve disease by a general heart team (2009-2014) and a dedicated mitral valve heart team (2014-2018) were included. Decision-making was recorded prospectively in heart team electronic forms. The end point was overall survival from decision of the heart team.
Results:
In total, 1145 patients were included of whom 641 (56%) were discussed by dedicated heart team and 504 (44%) by general heart team. At 5 years, survival probability was 0.74 [95% confidence interval (CI) 0.68-0.79] for the dedicated heart team group compared to 0.70 (95% CI 0.66-0.74, P = 0.040) for the general heart team. Relative risk of mortality adjusted for EuroSCORE II, treatment groups (surgical, transcatheter and non-intervention), mitral valve pathology (degenerative, functional, rheumatic and others) and 13 other baseline characteristics for patients in the dedicated heart team was 29% lower [hazard ratio (HR) 0.71, 95% CI 0.54-0.95; P = 0.019] than for the general heart team. The adjusted relative risk of mortality was 61% lower for patients following the advice of the heart team (HR 0.39, 95% CI 0.25-0.62; P < 0.001) and 43% lower for patients following the advice of the general heart team (HR 0.57, 95% CI 0.37-0.87; P = 0.010) compared to those who did not follow the advice of the heart team.
Conclusions:
In this retrospective cohort, patients treated for mitral valve disease based on a dedicated heart team decision have significantly higher survival independent of the allocated treatment, mitral valve pathology and baseline characteristics.
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