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Risk factors associated with diabetic neuropathy in Mexican patients
Katy Sánchez-Pozos1, Jazmín Monroy-Escutia1, Joel Jaimes-Santoyo1
1Laboratory of Molecular Endocrinology, Hospital Juárez de México.
Cirugia Y Cirujanos
|March 30, 2021
Summary
Diabetic neuropathy (DN) affects 28.3% of type 2 diabetes (T2D) patients in Mexico. Key risk factors include longer T2D duration, poor glycemic control, altered lipid levels, metformin use, diabetic retinopathy, and smoking.
Area of Science:
- Endocrinology and Metabolism
- Neurology
- Public Health
Background:
- Diabetic neuropathy (DN) is a prevalent complication of type 2 diabetes (T2D), significantly increasing the risk of lower limb amputation.
- Understanding the specific risk factors for DN in diverse populations, such as Mexicans, is crucial for targeted prevention and management strategies.
Purpose of the Study:
- To identify and analyze the key risk factors associated with the development of diabetic neuropathy in a Mexican cohort of type 2 diabetes patients.
- To compare characteristics between T2D patients with and without DN to elucidate contributing factors.
Main Methods:
- A cross-sectional study involving 509 Mexican participants diagnosed with T2D.
- Diabetic neuropathy assessment using the Douleur Neuropathique 4 (DN4) questionnaire.
- Logistic regression analysis to determine the statistical significance of identified risk factors.
Main Results:
- The prevalence of DN in the study population was 28.3%.
- Significant risk factors for DN included longer T2D duration (OR: 2.51), higher glycemic exposure index (OR: 1.82), altered low- and high-density lipoprotein levels (OR: 1.53), metformin treatment (OR: 2.08), diabetic retinopathy (OR: 1.65), and smoking (OR: 1.51).
Conclusions:
- Early identification of these risk factors in the Mexican population is essential for developing personalized management strategies.
- Implementing targeted interventions can improve the quality of life for T2D patients and potentially reduce national healthcare expenditures.
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