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Related Concept Videos

Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
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Relationships between intraindividual cognitive variability, self-reported cognitive dysfunction, and functional difficulties in persons with multiple sclerosis: a preliminary investigation.

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Perceived Fatigue Impact and Cognitive Variability in Multiple Sclerosis.

Kaitlin E Riegler1, Margaret Cadden1,2, Erin T Guty1

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Journal of the International Neuropsychological Society : JINS
|March 31, 2021
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Summary

Cognitive variability, or intraindividual variability (IIV), significantly impacts fatigue in people with Multiple Sclerosis (PwMS). This objective performance measure highlights how variable performance may exacerbate fatigue experienced by PwMS compared to healthy controls (HCs).

Keywords:
Central nervous systemCognitionCognitive dysfunctionNeurodegenerative diseasesNeuropsychological testsSelf-report

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Area of Science:

  • Neuroscience
  • Psychology
  • Clinical Medicine

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease impacting cognitive function and causing significant fatigue.
  • Understanding the relationship between cognitive performance variability and fatigue is crucial for managing MS.
  • Intraindividual variability (IIV) is an emerging metric for assessing cognitive function fluctuations.

Purpose of the Study:

  • To investigate the relationship between fatigue and cognitive variability in people with Multiple Sclerosis (PwMS) compared to healthy controls (HCs).
  • To determine if intraindividual variability (IIV) mediates the association between MS status and fatigue.
  • To explore the impact of IIV in attention/processing speed and memory domains on fatigue.

Main Methods:

  • A cohort of 59 PwMS and 51 HCs underwent neuropsychological testing and completed fatigue and depression questionnaires.
  • Intraindividual variability (IIV) was measured using maximum discrepancy score (MDS) and intraindividual standard deviation (ISD) in memory and attention/processing speed.
  • Mediation analyses, including the Baron and Kenny approach and PROCESS macro, were employed to test the indirect effect of IIV on fatigue.

Main Results:

  • Intraindividual variability (IIV) in both attention/processing speed and memory domains significantly mediated the effect of patient status on total residual fatigue.
  • PwMS exhibited greater cognitive variability across memory and attention/processing speed tests compared to HCs.
  • This increased variability in performance was linked to a greater impact of fatigue.

Conclusions:

  • Intraindividual variability (IIV) serves as an objective performance measure correlating with fatigue differences between PwMS and HCs.
  • Elevated cognitive variability in PwMS may contribute to or exacerbate their experience of fatigue.
  • Targeting cognitive variability could be a potential strategy for mitigating fatigue in Multiple Sclerosis management.