Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.6K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineered human plasma-derived cryogels as a multifunctional scaffold to promote diabetic wound healing.

Materials today. Bio·2026
Same author

Human serum albumin-based cryogels as a biomimetic platform for 3D co-culture and drug-induced liver injury prediction.

International journal of biological macromolecules·2025
Same author

Hyperglycemia-responsive nitric oxide-releasing biohybrid cryogels with cascade enzyme catalysis for enhanced healing of infected diabetic wounds.

Journal of controlled release : official journal of the Controlled Release Society·2024
Same author

Arginine-loaded globular BSAMA/fibrous GelMA biohybrid cryogels with multifunctional features and enhanced healing for soft gingival tissue regeneration.

International journal of biological macromolecules·2024
Same author

Small nucleolar RNA expression profiles: A potential prognostic biomarker for non-viral Hepatocellular carcinoma.

Non-coding RNA research·2024
Same author

Emerging role of circulating cell-free RNA as a non-invasive biomarker for hepatocellular carcinoma.

Critical reviews in oncology/hematology·2024

Related Experiment Video

Updated: Nov 11, 2025

Mammary Epithelial Transplant Procedure
08:51

Mammary Epithelial Transplant Procedure

Published on: June 10, 2010

31.4K

Pristane-induced mammary carcinomas.

Dattatrya Shetti1, Bae Hoon Lee1

  • 1Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.

Methods in Cell Biology
|March 31, 2021
PubMed
Summary

This study details a protocol for creating pristane-induced breast cancer models in mice. These models aid in studying breast cancer development and evaluating new therapeutic drugs.

Keywords:
Breast cancerMammary fat padPaclitaxelPristaneTumor modelXAV939

More Related Videos

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.5K
Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
06:29

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland

Published on: June 7, 2019

13.1K

Related Experiment Videos

Last Updated: Nov 11, 2025

Mammary Epithelial Transplant Procedure
08:51

Mammary Epithelial Transplant Procedure

Published on: June 10, 2010

31.4K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.5K
Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
06:29

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland

Published on: June 7, 2019

13.1K

Area of Science:

  • Oncology
  • Carcinogenesis
  • Pharmacology

Background:

  • Chemically induced breast tumor models are valuable for studying human breast cancer.
  • Pristane is a hydrocarbon oil used as a chemical carcinogen.
  • Pristane-induced breast cancer models are infrequently reported.

Purpose of the Study:

  • To describe the pristane-induced mammary carcinoma model in mice.
  • To provide a detailed protocol for generating these models.
  • To facilitate research on breast cancer and therapeutic testing.

Main Methods:

  • Induction of mammary tumors in mice using pristane.
  • Detailed protocol for model generation and application.
  • Adaptability of the protocol for other animal models.

Main Results:

  • Successful generation of pristane-induced breast tumors in mice.
  • Establishment of a reproducible protocol for breast cancer modeling.
  • Demonstration of the model's utility for therapeutic evaluation.

Conclusions:

  • Pristane-induced mammary carcinoma models offer a viable approach for breast cancer research.
  • The provided protocol enables standardized model generation.
  • This model system supports the investigation of breast cancer progression and treatment efficacy.