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Parkin: A targetable linchpin in human malignancies

Ahmad Perwez1, Khushnuma Wahabi1, Moshahid A Rizvi1

  • 1Genome Biology Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.

Biochimica Et Biophysica Acta. Reviews on Cancer
|March 31, 2021
PubMed

Insights

Parkin, an E3 ubiquitin ligase, is crucial in cancer pathogenesis by regulating key hallmarks like proliferation and apoptosis. Its dysfunction contributes to tumor progression, highlighting its potential as a therapeutic target and biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Parkin, an E3 ubiquitin ligase, is frequently deregulated in human cancers.
  • Evidence suggests Parkin plays a critical role in cancer pathogenesis by influencing major cancer hallmarks.

Purpose of the Study:

  • To review the current knowledge on Parkin's role in cancer development and progression.
  • To highlight Parkin's therapeutic implications, including its diagnostic and prognostic value as a biomarker.

Main Methods:

  • Literature review focusing on Parkin's function in cancer.
  • Analysis of Parkin's involvement in cancer hallmarks such as proliferation, migration, angiogenesis, and apoptosis.
  • Examination of Parkin's role in cell cycle regulation and genomic stability.

Main Results:

  • Parkin's tumor-suppressive potential is linked to its regulation of mitophagy, cell proliferation, migration, angiogenesis, apoptosis, and cellular survival.
  • Parkin dysfunction leads to accumulation of cell cycle components, genomic instability, and tumor progression.
  • Parkin exhibits diagnostic and prognostic value as a potential cancer biomarker.

Conclusions:

  • Understanding Parkin's multifaceted role in cancer is essential for developing targeted therapies.
  • Parkin represents a promising therapeutic target and biomarker for various human cancers, opening new avenues for clinical applications.
Keywords:
BiomarkerCancerE3 ubiquitin ligaseParkin (PARK2/PRKN)TherapeuticsTumor suppressor gene

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