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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

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Early infections after successful transcatheter aortic valve replacement are associated with increased short- and

Vincenzo De Marzo1, Silvia Dettori2, Laura Ambra Nicolini3

  • 1DICATOV - Cardiothoracic and Vascular Department, San Martino Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy; Department of Internal Medicine and Medical Specialties (Di.M.I.), Chair of Cardiovascular Diseases, University of Genoa, Genoa, Italy.

International Journal of Cardiology
|March 31, 2021
PubMed
Abstract

Insights

Early infections after transcatheter aortic valve replacement (TAVR) affect about 1 in 10 patients and are linked to higher mortality rates. Close monitoring of TAVR patients with infections may improve outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Device Technology

Background:

  • Transcatheter aortic valve replacement (TAVR) is a crucial procedure for aortic stenosis.
  • Understanding early post-TAVR infections is vital for patient management and outcomes.

Purpose of the Study:

  • To investigate the frequency, microbiological characteristics, predictors, and outcomes of early infections following TAVR.
  • To assess the impact of early infections on short- and long-term mortality after TAVR.

Main Methods:

  • A retrospective review of 539 patients who underwent successful TAVR between 2014 and 2019.
  • Definition of early infections as those occurring within 30 days post-TAVR.
  • Multivariable analysis to identify predictors and associations with mortality.

Main Results:

  • Early infections occurred in 11.3% of TAVR patients.
  • Pulmonary infections were most common (42.9%), followed by bloodstream infections (15.9%).
  • Early infections were independently associated with increased 30-day and 1-year mortality.

Conclusions:

  • Approximately 1 in 10 TAVR patients experience early infections, significantly increasing mortality risk.
  • While causality is complex, vigilant surveillance of TAVR patients with infections is recommended.
  • Improved monitoring may enhance TAVR procedure success rates and patient survival.
Keywords:
Aortic valveInfectionsProphylaxisTAVR

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