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Grey matter abnormality in progressive multifocal leucoencephalopathy

Christopher Yuki Itoh1, Han Sung Lee2, Alan Howe Yee3

  • 1Department of Neurology, University of California Davis School of Medicine, Sacramento, California, USA citoh@ucdavis.edu.

Practical Neurology
|March 31, 2021
PubMed

Insights

Progressive multifocal leukoencephalopathy (PML) involves grey matter, challenging typical white matter disease imaging. This study details the rare radiological and histopathological findings of grey matter involvement in PML.

Area of Science:

  • Neurology
  • Neuroimaging
  • Pathology

Background:

  • Progressive multifocal leukoencephalopathy (PML) is a rare, opportunistic demyelinating disease affecting the brain's white matter.
  • JC virus infection is the primary cause of PML, predominantly in immunocompromised individuals.
  • Current diagnostic standards rely on detecting viral DNA or protein in tissue via histopathology.

Observation:

  • This case report focuses on the neuroimaging and histopathological features of cerebral grey matter involvement in PML.
  • It addresses a gap in the literature regarding detailed descriptions of grey matter pathology in PML.
  • The study presents a patient with biopsy-proven PML and associated grey matter abnormalities.

Findings:

  • Histopathological examination revealed the specific changes in grey matter consistent with PML.
  • Neuroimaging findings correlated with the observed grey matter pathology.
  • This provides a detailed description of the radiological appearance of grey matter PML.

Implications:

  • Enhanced understanding of PML's potential to affect grey matter.
  • Improved diagnostic accuracy through recognition of grey matter imaging patterns.
  • Potential for earlier detection and management of PML in affected patients.
Keywords:
CSFinfectious diseasesneuropathologyneuroradiologyvirology

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