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Ornithine decarboxylase activity in prostate cancer
О А Samoylenko1, E O Stakhovsky2, Y V Vitruk2
1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kyiv 03022, Ukraine.
Experimental Oncology
|March 31, 2021
Summary
Ornithine decarboxylase activity (AODC) may serve as an auxiliary biomarker for prostate cancer (PCa) diagnosis. Elevated AODC correlates with higher Gleason scores and advanced clinical stages in PCa patients.
Area of Science:
- Oncology
- Biochemistry
- Urology
Background:
- Prostate cancer (PCa) is a common malignancy in men, with diagnosis relying on Gleason score and prostate-specific antigen (PSA).
- Current diagnostic methods for PCa have limitations, necessitating the exploration of novel biomarkers.
- Ornithine decarboxylase activity (AODC) is proposed as a potential auxiliary biomarker for PCa detection and treatment monitoring.
Purpose of the Study:
- To investigate the relationship between AODC in PCa tissues and serum PSA levels.
- To correlate AODC and PSA with Gleason score (GS) and clinical stage in PCa patients.
Main Methods:
- Analysis of AODC in prostate cancer tissues from 29 patients using a modified spectrophotometric assay.
- Categorization of patients into low (<0.3) and high (>0.45) AODC groups.
- Correlation of AODC and serum PSA levels with Gleason score and clinical stage (T1-T4).
Main Results:
- Higher AODC levels were observed in patients with higher Gleason scores (9-10) compared to those with lower scores (6).
- Elevated AODC was also noted in patients with clinical stages T1 and T4.
- The highest serum PSA levels were detected in patients with advanced clinical stages (T3-T4) and high Gleason scores.
Conclusions:
- AODC and serum PSA patterns can serve as supplementary indicators for monitoring prostate cancer progression.
- AODC may offer additional value in assessing PCa severity and clinical stage.
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