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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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Lipoprotein Profiles before Heparin Administration in Patients with or without Coronary Thrombosis Following

Tomomi Koizumi1, Hideaki Kaneda2, Nobuyuki Komiyama3

  • 1Department of Cardiovascular Medicine, Mito Medical Center, National Hospital Organization, Higashi-Ibaraki, Ibaraki, Japan.

Annals of Vascular Diseases
|March 31, 2021
PubMed

Insights

Lipoprotein profiles in ST-segment elevation myocardial infarction (STEMI) patients with coronary arterial thrombosis (CAT) differ from controls. Intermediate-density lipoprotein was lower, and small dense low-density lipoprotein (s-LDL) was higher, though not universally present in STEMI patients.

Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Thrombosis Research

Background:

  • The relationship between lipoproteins and arterial thrombosis remains incompletely understood.
  • Limited data exist on lipoprotein profiles preceding heparin treatment in patients with coronary arterial thrombosis (CAT).

Purpose of the Study:

  • To investigate the lipoprotein profile before heparin administration in ST-segment elevation myocardial infarction (STEMI) patients with CAT.
  • To compare lipoprotein fractions in STEMI patients with CAT against a control group with stable coronary artery disease.

Main Methods:

  • A cross-sectional study involving 63 STEMI patients with CAT and age/sex-matched controls with <25% coronary artery stenosis.
  • Lipoprotein profiles were assessed using polyacrylamide gel electrophoresis prior to heparin administration for primary percutaneous coronary intervention.
  • Control subjects had stable coronary artery disease with minimal stenosis.

Main Results:

  • No significant difference in very-low-density lipoprotein fraction between STEMI patients and controls (P=0.75).
  • STEMI patients exhibited a significantly lower fraction of intermediate-density lipoprotein compared to controls (P<0.01).
  • A significantly higher fraction of small dense low-density lipoprotein (s-LDL) was observed in STEMI patients (P<0.01), yet 44% lacked detectable s-LDL.

Conclusions:

  • Lipoprotein profiles in STEMI patients with CAT differ from those in stable coronary artery disease patients without CAT.
  • While lipoproteins are established atherosclerosis risk factors, specific pre-heparin profiles in STEMI with CAT show distinct patterns.
  • The presence and fraction of s-LDL may vary even within STEMI patients experiencing CAT.

Keywords:
coronary artery diseaseheparinlipoproteinpolyacrylamide gel electrophoresisthrombosis

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