[Clinical and experimental research on the drug-metabolizing function of the liver in peritonitis]

It was found that in experimental peritonitis the activities of hepatic amidopyrine-N-dimethylase, aniline hydroxylase and NADPN cytochrome-C-reductase as well as the contents of cytochromes P-450 and B5 in the microsomal fraction of the liver significantly decrease and also there is prolongation of the half-life and reduction of the clearance of antipyrine. Similar changes in the drug pharmacokinetic were revealed also in the patients with developed and diffuse peritonitis, their degree being more significant in patients hospitalized in the toxic phase and especially in the terminal phase of the disease.