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Daptomycin-Induced Acute Eosinophilic Pneumonia

Gilda M Portalatin1, Jodi-Ann Chin1, Brian Foster2

  • 1Internal Medicine, Cleveland Clinic Florida, Weston, USA.

Cureus
|March 31, 2021
PubMed

Insights

Antibiotic treatment for pneumonia can rarely cause lung problems like daptomycin-induced acute eosinophilic pneumonia. Discontinuing the antibiotic and using steroids effectively treated the patient's symptoms.

Area of Science:

  • Pulmonology
  • Pharmacology
  • Infectious Diseases

Background:

  • Antibiotics are standard treatment for suspected bacterial pneumonia.
  • Drug-induced lung injury is an uncommon but serious adverse effect of some medications.
  • Daptomycin, an antibiotic, is associated with adverse effects including pulmonary eosinophilia.

Observation:

  • A patient presented with respiratory symptoms suggestive of multifocal pneumonia.
  • The patient was receiving daptomycin for a presumed bacterial infection.
  • Symptoms developed during daptomycin therapy, raising suspicion for drug-induced lung injury.

Findings:

  • The patient was diagnosed with probable daptomycin-induced acute eosinophilic pneumonia.
  • Cessation of daptomycin therapy led to symptom improvement.
  • Concurrent corticosteroid treatment aided in the resolution of pulmonary symptoms.

Implications:

  • This case highlights the importance of considering drug-induced pulmonary toxicity in patients with new-onset pneumonia symptoms during antibiotic treatment.
  • Prompt recognition and discontinuation of the offending agent, daptomycin, are crucial for managing daptomycin-induced acute eosinophilic pneumonia.
  • Steroid therapy may be beneficial in resolving daptomycin-induced lung injury.
Keywords:
acute eosinophilic pneumoniacoughdaptomycindaptomycin-induced acute eosinophilic pneumoniadaptomycin-induced pneumonitiseosinophilic pneumoniainfectious diseasemacrolide antibioticspneumoniashortness of breath

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