Extramedullary Multiple Myeloma with Hepatic Involvement

Area of Science:

• Hematology
• Oncology
• Hepatology

Background:

• Multiple myeloma (MM) is a plasma cell malignancy.
• Extramedullary multiple myeloma (EMM) involves plasma cell tumors outside the bone marrow.
• Hepatic involvement in MM/EMM is an uncommon but significant clinical finding.

Observation:

• Presents two distinct cases of EMM with hepatic space-occupying lesions.
• Highlights the diverse clinical presentations of liver involvement in MM.
• Hepatic lesions in EMM can mimic other liver pathologies.

Findings:

• Hepatic involvement by EMM signifies a poor prognosis.
• The clinical presentation of hepatic EMM is variable.
• Diagnosis requires integration of imaging, serology, and biopsy.

Implications:

• Early identification of hepatic EMM is essential for accurate staging.
• Recognizing hepatic EMM aids in treatment planning and prognostic assessment.
• Understanding this rare manifestation improves patient outcomes and clinical management.