Non-toxic doses of modified titanium dioxide nanoparticles (m-TiO₂NPs) in albino CFW mice

Modified titanium dioxide (m-TiO₂NPs) is a novel photocatalytic nanomaterial. Its level of toxicity was evaluated to be used in photodynamic treatment for cervical cancer. In the toxicity studies (Irwin test, acute and repeated doses (10 days)), female albino Swiss Webster (CFW) mice, 28 days old were used; the m-TiO₂NPs was administered in single 300, 600 and 5,000 mg/kg of body weight (b.w) doses injected in the peritoneal zone. No adverse events or mortality were produced. Daily intraperitoneal doses of 300 and 600 mg/kg b.w every 24 h for 10 days did not produce adverse effects or mortality. There were no abnormal clinical signs or behavioral changes (neurological or physiological) in any of the mice. All organs exhibited normal architecture, and histological studies determined that m-TiO₂NPs does not produce changes in the cells or tissues. Based on the test results, it is concluded that the m-TiO₂NPs has not a toxic effect in doses equal to or less than 5,000 mg/kg b.w.