Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA and multiple skin carcinomas.

D Cerimele1, L Contu, C Carcassi

  • 1Institute of Dermatology, University of Sassari, Italy.

Dermatologica
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment with gut bifidobacteria improves hippocampal plasticity and cognitive behavior in adult healthy rats.

Neuropharmacology·2019
Same author

Social enrichment reverses the isolation-induced deficits of neuronal plasticity in the hippocampus of male rats.

Neuropharmacology·2019
Same author

Spatial diffusion of surnames by long transhumance routes between highland and lowland: A study in Sardinia.

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen·2018
Same author

Lead isotopic fingerprint in human scalp hair: The case study of Iglesias mining district (Sardinia, Italy).

The Science of the total environment·2017
Same author

A genetic epidemiology study of congenital adrenal hyperplasia in Italy.

Clinical genetics·2017
Same author

HLA-G expression and role in advanced-stage classical Hodgkin lymphoma.

European journal of histochemistry : EJH·2016
Same journal

Radiodermatitis with late ulcer (sarcoma) for 34 years.

Dermatologica·2010
Same journal

Alopecia decalvans, totalis, maligna, with nail changes and tooth abnormalities.

Dermatologica·2010
Same journal

Epidermolysis bullosa tarda simplex.

Dermatologica·2010
Same journal

Blistering after psychological arousal.

Dermatologica·2010
Same journal

Mycosis fungoides in the tumor stage.

Dermatologica·2010
Same journal

Photoallergic rash after Irgafen.

Dermatologica·2010
See all related articles

Human Leukocyte Antigen (HLA) genes influence skin cancer risk. Certain HLA types, like B-17 (B-58), may offer resistance to developing multiple basal and squamous cell carcinomas.

Area of Science:

  • Immunogenetics
  • Dermatology
  • Oncology

Background:

  • Multiple skin carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), represent a significant health concern.
  • Genetic factors, particularly those within the Human Leukocyte Antigen (HLA) system, are known to play a role in immune response and disease susceptibility.
  • Investigating HLA associations can elucidate genetic predispositions and potential resistance mechanisms to cancer development.

Purpose of the Study:

  • To investigate the association between specific Human Leukocyte Antigen (HLA) antigens and the development of multiple basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs).
  • To identify potential HLA-associated genetic factors that confer resistance or susceptibility to these common skin cancers.

Main Methods:

Related Experiment Videos

  • A case-control study was conducted involving 43 patients with multiple BCCs and/or SCCs.
  • 220 healthy, age-matched individuals served as controls.
  • Both patients and controls were typed for 72 different HLA-A, B, C, and DR antigens.

    • Main Results:

    • A negative association was observed between HLA B-17 (predominantly B-58) and multiple BCCs.
    • Patients with multiple BCCs showed a positive association with HLA Cw-3 and HLA DR-1.
    • Similar associations were found for squamous cell carcinomas, with a negative association for HLA B-58 and a positive association for HLA DR-1.

    Conclusions:

    • The findings suggest that certain HLA antigens may act as genetic resistance factors against the development of multiple skin cancers.
    • Specifically, the HLA B-17 (B-58) antigen appears to be associated with a reduced risk of developing both basal cell and squamous cell carcinomas.
    • Further research into HLA-driven immune responses could inform strategies for skin cancer prevention.