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Arotinoid acid (Ro 13-7410): a pilot study in dermatology
J H Saurat1, Y Mérot, M Borsky
1Clinique de Dermatologie, Hôpital Cantonal Universitaire, Genève, Suisse.
Dermatologica
|January 1, 1988
Summary
This study investigated Ro 13-7410, a potent retinoid. While avoiding common toxicities, it frequently caused eczematous retinoid dermatitis at higher doses, suggesting a unique profile compared to other retinoids.
Area of Science:
- Dermatology
- Pharmacology
- Retinoid Research
Background:
- Retinoids are crucial in dermatology, but their clinical use is limited by toxicity.
- Ro 13-7410 is a novel, highly potent synthetic retinoid with high affinity for skin retinoic acid binding protein.
Purpose of the Study:
- To evaluate the safety and tolerability of Ro 13-7410 in patients.
- To characterize the unique toxicological profile of Ro 13-7410.
Main Methods:
- A pilot study involving 29 patients receiving 38 treatment courses of Ro 13-7410.
- Duration of treatment ranged from 4 to 23 weeks, with an average of 7.5 weeks.
Main Results:
- Ro 13-7410 did not induce typical mucocutaneous retinoid toxicity (scaling, cheilitis) at therapeutic doses.
- An eczematous retinoid dermatitis was frequently observed at doses exceeding 0.5 microgram/kg/day.
Conclusions:
- Ro 13-7410 exhibits a distinct pharmacological profile compared to previously studied retinoids.
- The high potency and unique side effect profile warrant further investigation for potential therapeutic applications.