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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Re: Bobelyak M, Vaculik J, Stepan JJ. Bone mineral density assessment using Radiofrequency Echographic Mult Spectrometry (REMS) in patients before and after total hip replacement, Osteoporos Int 2025;https://doi.org/10.1007/s00198-025-07685-w and Re: Pocock N, Chan D. Editorial: Is REMS-BMD truly a measured parameter? A call for transparency and technical clarification, Osteoporos Int 2025;https://doi.org/10.1007/s00198-025-07699-4.

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Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
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SARC-F Questionnaire Detects Frailty in Older Adults.

G Bahat1, S Ozkok, C Kilic

  • 1Gulistan Bahat, Istanbul University, Istanbul Medical School, Department of Internal Medicine, Capa, 34390, Istanbul, Turkey, Telephone: + 90 212 414 20 00-33204, Fax: + 90 212 532 42 08,

The Journal of Nutrition, Health & Aging
|March 31, 2021
PubMed
Summary
This summary is machine-generated.

The SARC-F questionnaire, used for sarcopenia screening, can effectively screen and evaluate frailty in older adults. A score of 1 or more indicates high sensitivity for frailty screening, while a score of 4 or more suggests high specificity for diagnosis.

Keywords:
Sarcopeniadiagnosisfrailtygeriatric practicescreening

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Area of Science:

  • Geriatric Medicine
  • Aging Research
  • Diagnostic Tool Validation

Background:

  • Frailty and sarcopenia share overlapping physical phenotypes.
  • The SARC-F questionnaire is recommended for sarcopenia screening by EWGSOP2.
  • Investigating SARC-F's utility for frailty assessment is warranted due to condition overlap.

Purpose of the Study:

  • To determine if the SARC-F questionnaire is a valid and reliable tool for screening or evaluating frailty.
  • To assess the diagnostic accuracy of the SARC-F questionnaire for identifying frailty in older adults.

Main Methods:

  • Retrospective, cross-sectional study design.
  • Involved 447 older adults (mean age 74.5 years, 70.7% female).
  • Frailty assessed using the modified Fried scale; SARC-F questionnaire administered to all participants. Receiver operating characteristic (ROC) curve analysis used to determine SARC-F cut-off values.

Main Results:

  • 20.8% of participants were identified as frail by the modified Fried scale.
  • SARC-F cut-off ≥1 demonstrated high sensitivity (91.4%) for frailty screening.
  • SARC-F cut-off ≥2 offered the best balance of sensitivity (74.1%) and specificity (73.7%) for frailty identification (AUC: 0.807).
  • SARC-F cut-off ≥4 showed high specificity (92.6%) for frailty diagnosis.

Conclusions:

  • SARC-F ≥1 can be utilized as a sensitive screening tool for frailty.
  • SARC-F ≥4 can be employed as a specific diagnostic tool for frailty.
  • The SARC-F questionnaire shows potential for evaluating frailty in routine geriatric practice.